Relationship between liver fibrosis and in-hospital outcomes in patients with acute coronary syndrome undergoing PCI

Abstract Background Patients with acute coronary syndrome (ACS) undergoing percutaneous intervention (PCI) still experience a high rate of in-hospital complications. Liver fibrosis (LF) is risk factor for mortality in the general population. However its prognostic role ACS patients has been poorly investigated. Purpose We investigated whether presence LF detected by validated fibrosis-4 (FIB-4) score may indicate at higher poor outcome. Methods In prospective ongoing REAl-world observationaL rEgistry Acute Coronary Syndrome (REALE-ACS), was defined FIB-4 >3.25. The primary endpoint adverse events (AEs) including composite cardiogenic shock, PEA/asystole, pulmonary edema and death. Results A total 469 consecutive were enrolled. Overall, 21.1% had older, less frequently on P2Y12 inhibitors (p=0.021) admitted serum levels white blood cells (p<0.001), neutrophils to lymphocytes ratio C-reactive protein (p=0.013), high-sensitive troponin T creatin-kinase MB D-Dimer (p<0.001). STEMI presentation Killip class/GRACE more common group 71 experienced 110 AEs. At multivariate analysis clinical laboratory factors, >3.25 (OR 3.1, 95% CI 1.4 6.9), admission left ventricular ejection fraction% below median 9.2, 3.9 21.7) class ≥II 6.3, 2.2 18.4) strongest independent predictors Conclusions associated severe worse AEs irrespective variables. Funding Acknowledgement Type funding sources: None.